Gene information
Official symbol TIMP4
Official full name TIMP metallopeptidase inhibitor 4
Gene type protein-coding gene
Chromosome3p25.2
Gene familyTissue inhibitor of metallopeptidases
Resources
Entrez Gene 7079
HGNC HGNC:11823
Ensembl ENSG00000157150
Vega OTTHUMG00000129763
UCSC uc003bwo.4
GO terms: 34 records
GO Description Category LogP Number of genes Detail
GO:0002020 protease binding GO Molecular Functions -28.8254555 31 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0004857 enzyme inhibitor activity GO Molecular Functions -18.4005452 35 More
GO:0004866 endopeptidase inhibitor activity GO Molecular Functions -20.0646267 27 More
GO:0008191 metalloendopeptidase inhibitor activity GO Molecular Functions -5.83914312 5 More
GO:0009410 response to xenobiotic stimulus GO Biological Processes -32.6021211 82 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009895 negative regulation of catabolic process GO Biological Processes -10.3621088 43 More
GO:0010466 negative regulation of peptidase activity GO Biological Processes -24.1438543 35 More
GO:0010951 negative regulation of endopeptidase activity GO Biological Processes -24.7873219 35 More
GO:0030016 myofibril GO Cellular Components -10.5185909 20 More
GO:0030017 sarcomere GO Cellular Components -8.52596130 17 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030414 peptidase inhibitor activity GO Molecular Functions -19.6181890 27 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031330 negative regulation of cellular catabolic process GO Biological Processes -6.88355184 32 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0042176 regulation of protein catabolic process GO Biological Processes -8.45353494 23 More
GO:0042177 negative regulation of protein catabolic process GO Biological Processes -5.18322511 10 More
GO:0042698 ovulation cycle GO Biological Processes -6.53718605 9 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043292 contractile fiber GO Cellular Components -11.9705216 22 More
GO:0043434 response to peptide hormone GO Biological Processes -26.1739008 69 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0048511 rhythmic process GO Biological Processes -10.3377021 38 More
GO:0051043 regulation of membrane protein ectodomain proteolysis GO Biological Processes -16.3022563 12 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0061134 peptidase regulator activity GO Molecular Functions -19.3582235 29 More
GO:0061135 endopeptidase regulator activity GO Molecular Functions -19.1908633 27 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
Related studies: 4 records
Molecular factor Omics type Application Objective MI type Reference
metalloproteinase inhibitor 4 proteomics hypertrophic cardiomyopathy[prognosis (bad)] myocardial infarction Stroud RE et al. J Card Fail. 2005
metalloproteinase inhibitor 4 proteomics left ventricular remodeling[prognosis (bad)] acute myocardial infarction Weir RA et al. J Card Fail. 2011
metalloproteinase inhibitor 4 proteomics poor predictor major adverse cardiovascular events[prognosis (bad)] acute myocardial infarction Kelly D et al. Am J Cardiol. 2010
metalloproteinase inhibitor 4 proteomics myocardial infarction[diagnosis] myocardial infarction Cavusoglu E et al. Am J Cardiol. 2017
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